Workshop Report Folate and colo-rectal cancer risk
نویسندگان
چکیده
Peter Sanderson, Elaine Stone*, Young-In Kim, John C. Mathers, Ellen Kampman, C. Stephen Downes, Kenneth R. Muir and John A. Baron Nutrition Division, Food Standards Agency, London WC2 6NH, UK Division of Gastroenterology, University of Toronto, Toronto, Canada Human Nutrition Research Centre, University of Newcastle, Newcastle-upon-Tyne, UK Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands School of Biomedical Sciences, University of Ulster,Coleraine, UK Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK Biostatistics & Epidemiology Evergreen Center, Dartmouth College, Hanover, NH, USA
منابع مشابه
Folate and colo-rectal cancer risk.
The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate and colo-rectal cancer risk. The workshop aimed to examine current research and establish research priorities. The timing of folate exposure with respect to carcinogenesis, as well as the dose and form of folate, were considered key issues for future research. Also, the need to stu...
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Lower levels of dietary folate are associated with the development of epithelial cell tumours in man, particularly colo-rectal cancer. In the majority of epidemiological studies blood folate or reported folate intake have been shown to be inversely related to colo-rectal cancer risk. Folate, via its pivotal role in C1 metabolism, is crucial both for DNA synthesis and repair, and for DNA methyla...
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In early epidemiological studies of diet and cancer the stress was on the search for causal factors. Population (ecological) studies tended to show a strong correlation between meat intake, particularly red meat, and the risk of colo-rectal cancer. They also tended to show meat to be strongly inversely correlated with cancers of the stomach and oesophagus and liver. Early case-control studies t...
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